James Duffy may refer to:

• James E. Duffy, Jr. (born 1942), U.S. Democrat nominee for the Hawaii Supreme Court and former federal judicial nominee to the U.S. Court of Appeals for the Ninth Circuit
• James Duffy (psychiatrist), neuropsychiatrist and associate professor of clinical psychiatry at the University of Connecticut
• James Duffy (Irish publisher) (1809-1871), Irish publisher of Nationalist and Roman Catholic books, bibles and religious texts
• James Duffy (athlete) (1890-1915), winner of the 1914 Boston Marathon
• James Duffy (VC) (1889-1969), Irish recipient of the Victoria Cross in 1917
• James Duffy, a character in the short story "A Painful Case" (part of the book Dubliners) by James Joyce
• James Duffy (cricketer)
• James Albert Duffy (died 1968), first bishop for the Diocese of Grand Island
• James F. Duffy, American football coach
• James P.B. Duffy (1878-1969), former U.S. Congressman from New York
• Jamie Duffy (born 1983), Irish footballer
• Jim Duffy (journalist) (born 1966), journalist, political commentator, and Irish advisor to Australia's Republic Advisory Committee
• Jim Duffy (footballer) (born 1959), former caretaker manager of Norwich City F.C.
• Jim Duffy (rugby league), rugby league footballer
• Jim Duffy (journalist) (born 1966), Irish historian and political commentator

[ Source: Wikipedia ]