Early life

Chambers was born in Springfield, Ohio, on July 11, 1970 to Pamela Sue (Willman) and John William Eugene Chambers II, who were both deputy sheriffs. Chambers was brought up in Springfield and growing up he aspired to be a dentist. He has a fraternal twin brother named Jason, one older brother John Jr. (Chip), and two older sisters, Mia and Susan. He and his twin brother visited hospitals often as children due to frequent bouts with pneumonia. He attended Southeastern High School in South Charleston, Ohio, and later moved to New York and studied for four years at H.B. Studios and Ron Stetson Studios. Chambers was

Career

Chambers was discovered by a modelling scout on the Metro and went on to star in ad campaigns for Calvin Klein's fragrance range. He worked throughout Europe, Japan, and the United States for Calvin Klein, Armani, and Dolce & Gabbana. After deciding on an acting career, he moved to New York, where he studied at the HB Studio. Studios and Ron Stetson Studios for four years. That landed him a few television roles, including recurring role in soap opera Another World as Nicholas Hudson, and New York Undercover. In 1998 he was cast as series regular in the short-lived CBS primetime soap opera Four Corners. Chambers also appeared in several television movies, such as Harvest of Fire, Rose Hill, and Seasons of Love

Chambers starred in several movies, notably Liberty Heights (1999, as Trey, alongside Adrien Brody),The Wedding Planner (2001, as Massimo, alongside Jennifer Lopez), The Musketeer (2001) Southern Belles (2005), The Zodiac (2005), and the HBO original movie Hysterical Blindness (2002). In 2003, Chambers was cast as one of the leads in the CBS crime drama Cold Case but left after appearing in only four episodes.

In August, 2004, Chambers was cast as surgical intern Alex Karev in Shonda Rhimes's medical drama series Grey's Anatomy, opposite Ellen Pompeo, Sandra Oh, Katherine Heigl, and T. R. Knight. In 2006, along with other cast members, he was awarded a Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series. In 2009, he also guest-starred on the Grey's Anatomy spin-off, Private Practice, for the Grey's Anatomy/Private Practice crossover event.

Personal life

In 1993, he married Keisha Chambers, a former model agency booker. The two met at a meeting while Chambers was working for ad campaigns for Calvin Klein and Keisha was working at a modeling agency. The couple has five children together. Isabella (b. December 1994), twins Maya and Kaila (b. June 1997), Eva (b. March 1999) and Jackson (b. January 2002). They have adopted two rescue dogs and also own a beagle.

Chambers is involved with the non-profit Pentecostal Christian Church mission Dream Center of Los Angeles. In late January 2008, Chambers admitted that he suffered from a biological sleep disorder. The actor checked himself into Los Angeles's UCLA Medical Center to treat exhaustion due to the sleep disorder after a period of getting only two hours of sleep each week. He follows a healthy lifestyle and also practices hot yoga.

Filmography

Film

Year	Title	Role	Notes
1999	Liberty Heights	Trey Tobelseted
2001	The Wedding Planner	Massimo
2001	The Musketeer	D'Artagnan
2002	Leo	Ryan Eames
2003	For Which It Stands	German Soldier	Short film
2005	Southern Belles	Rhett Butler
2005	The Zodiac	Inspector Matt Parish
2008	Lakeview Terrace	Donnie Eaton
2010	The Happiest Man Alive	Sherman	Short film
2013	Broken City	Ryan Blake
2013	Justice League: The Flashpoint Paradox	The Flash / Barry Allen	Direct-to-video

Television

Year	Title	Role	Notes
1995	Another World	Nicholas 'Nick' Hudson #1	Recurring role
1996	New York Undercover	Officer Nick Caso	Episode: "Unis"
1996	Harvest of Fire	George	TV Movie
1996	Swift Justice	Rick	Episode: "Stones"
1997	Rose Hill	Cole Clayborne	TV Movie
1998	Four Corners	Caleb Haskell	Series regular (2 episodes)
1999	Seasons of Love	Adult Hocking	TV Movie
2002	Hysterical Blindness	Rick	TV Movie
2003	Cold Case	Chris Lassing	Series regular (5 episodes)
2004	The Secret Service	Charles Brody	TV pilot
2005-present	Grey's Anatomy	Dr. Alex Karev	Series regular (Season 1-present)
2009	Private Practice	Dr. Alex Karev	Episode: "Ex-Life"

Awards and Nominations

• Nominated - Teen Choice Award: Choice TV Breakout Performance - Male (2005)
• Nominated - Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series (2006, 2008)
• Won - Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series (2007)
• Nominated - Monte-Carlo Television Festival Award for Outstanding Actor - Drama Series (2007)
• Won - Satellite Award for Best Cast - Television Series (2006)
• Nominated - Prism Award for Performance in a Drama Series Episode (2008)
• Nominated - Prism Award for Performance in a Drama Series Multi-Episode Storyline (2009)
• Won - Prism Award for Performance in a Drama Series Multi-Episode Storyline (2014)
• Nominated - People's Choice Award for Favorite Dramatic TV Actor (2015)
• Nominated - People's Choice Award for Favorite Dramatic TV Actor (2016)

[ Source: Wikipedia ]