William Williams (artist) (1727-1791), artist, author of first American novel, Penrose
William Joseph Williams (1759-1823), his son, artist; painted George Washington, John Adams and Thomas Jefferson
William Williams (Crwys) (bardic name Crwys, 1875-1968), Welsh language poet
William Appleman Williams (1921-1990), American historian
William Carlos Williams (1883-1963), American poet
Sir William Emrys Williams (1896-1977), British educationalist and editor-in-chief of Penguin Books, 1936-1965
William Williams (surgeon) (1856-1919), Surgeon General
William T. Williams (born 1942), New York painter
Military figures
William Williams (VC) (1890-1965), Victoria Cross recipient of World War I
William Charles Williams (1880-1915), Victoria Cross recipient of World War I
William Williams (Medal of Honor) (1840-?), Medal of Honor recipient of the American Civil War
Sir William Williams, 1st Baronet, of Kars (1800-1883), Canadian-born British military leader
Politicians
Sir William Williams, 1st Baronet, of Gray's Inn (1634-1700), Welsh lawyer & politician, speaker of the House of Commons
Sir William Williams, 2nd Baronet, of Gray's Inn (c. 1665-1740), Welsh politician, Member of Parliament (MP) for Denbigh, 1708-1710
William Peere Williams (1664-1736), MP for Bishop's Castle, 1722-1727
Sir William Williams, 2nd Baronet, of Clapton (c. 1730-1761), MP for New Shoreham, 1758-1751
William Williams (Continental Congress) (1731-1811), U.S. Continental Congressman; signer of the Declaration of Independence for Connecticut.
William Williams (Radical politician) (1788-1865), Welsh businessman based in London, Radical MP 1835-1847 and 1850-1865
William Williams (New York) (1815-1876), US Representative from New York
William Williams (Indiana) (1821-1896), US Representative from Indiana
William B. Williams (politician) (1826-1905), US Representative from Michigan
William E. Williams (1857-1921), U.S. Representative from Illinois
W. Llewelyn Williams (1867-1922), Welsh journalist, lawyer and Liberal Party politician
William R. Williams (1884-1972), US Representative from New York
William Richard Williams (1895-1963), British civil servant and politician
William Hume-Williams (1863-1947), Conservative Party politician in the United Kingdom
Sir William Thomas Williams (UK politician) (1915-1986), British Member of Parliament for Warrington
William Williams (Swansea MP) (1840-1904), British Member of Parliament for Swansea District 1893-1895
Sir William Williams, 6th Baronet (c. 1668-1696), Welsh politician
William Williams (Tasmanian politician) (1851-1924), member of the Tasmanian Legislative Council
William M. "Buckskin" Williams, member of the First to Fourth and Sixth Texas Legislatures
William R. Williams (California politician), California State Treasurer, 1907-1911
William Addams Williams, British Member of Parliament for Monmouthshire
Religious figures
William Williams (bishop) (1800-1878), bishop of Waiapu in New Zealand
William Leonard Williams (bishop) (1829-1916), third bishop of Waiapu in New Zealand
William Williams (priest) (1848-1930), Dean of St David's, 1919-1931
William Williams Pantycelyn (1717-1791), religious leader & musician
William Williams of Wern (1781-1840), Welsh Independent minister; promoter of the "General Union" movement of 1834
William Richard Williams (theologian) (1896-1962), theologian and principal of the United Theological College Aberystwyth
Sportsmen
William Henry Williams (rugby player) (1873-1936), rugby union footballer of the 1900s for Wales, Pontymister RFC, and London Welsh RFC.
William Williams (rugby league), rugby league footballer of the 1900s and 1910s for Wales, and Halifax.
William Williams (rugby player) (1866-1945), rugby union footballer of the 1880s and 1890s for Wales, Cardiff RFC, and London Welsh RFC.
Billy Williams (rugby) (1905-1973), rugby union and rugby league footballer of the 1920s and 1930s for Wales (RU), Cross Keys RFC, Crumlin RFC, Great Britain (RL), Wales, and Salford.
William Williams (rugby) (1925-2007), rugby union and rugby league footballer of the 1940s for Wales XV (RU), Monmouthshire, Newport, and Swinton (RL).
Billy Williams (rugby player), (born 1929) rugby union footballer of the 1950s for Wales, and Swansea RFC.
William Williams (footballer born 1856), Welsh international footballer of the 1870s and 1880s
John Williams (footballer born 1960), English soccer player (born William John Williams)
William M. Williams, Clemson college football program from 1897
William David Williams, Blackpool and Everton footballer of the 1920s