William Little may refer to:

• William Brian Little (1942-2000), founding partner of Forstmann Little & Company, a private equity firm
• William Carruthers Little (1820-1881), Ontario farmer and political figure
• William John Little, English surgeon who identified cerebral palsy in children
• William Little (Australian poet), 19th century Australian fiction writer and poet, see 1916 in poetry
• William Little (Pittsburgh mayor), politician in Pittsburgh
• William Little (rugby league), rugby league footballer of the 1900s for England, and Halifax
• William Little (rugby league born circa-1910), rugby league footballer of the 1930s for England, and Barrow
• William Grady Little, former manager of the Boston Red Sox and Los Angeles Dodgers

[ Source: Wikipedia ]