Patrick Michael Pacillo (born July 23, 1963) is a former Major League Baseball player who pitched for the Cincinnati Reds in 1987 and 1988. He was drafted by the Cincinnati Reds in the 1st round (5th pick) of the 1984 amateur draft out of Seton Hall University, where he had played baseball for the Pirates under head coach Mike Sheppard.

He debuted on May 23, 1987. In his debut he pitched 5 innings and gave up 2 earned runs while striking out 3. In 1988 Pat was traded to the Montreal Expos along with Tracy Jones for Randy St. Claire, Jeff Reed, and Herm Winningham. He never pitched in the majors again.

Pacillo grew up in Rutherford, New Jersey and played both baseball and football at Rutherford High School.

Pacillo is perhaps best remembered for replacing Pete Rose on the Reds' 40-man roster following the 1986 season. Rose, who by that point was serving as the team's player-manager, removed himself from the roster in order to make room for Pacillo.

A resident of Bradley Beach, New Jersey, Pacillo works as a financial adviser.