Miles O'Brien may refer to:

• Miles M. O'Brien (1852-1910), banker and former president of the New York City Board of Education
• Miles W. O'Brien, co-founder of the South Bend Lathe Works
• Miles O'Brien (journalist) (born 1959), news journalist
• Miles O'Brien (Star Trek), a fictional character from Star Trek: The Next Generation and Star Trek: Deep Space Nine

[ Source: Wikipedia ]