John Wayne Ennis (born October 17, 1979) is a former Major League Baseball right-handed relief pitcher. Ennis made his Major League Baseball debut on April 10, 2002, with the Atlanta Braves.
Ennis pitched 4 innings in his first major league game; however, that one appearance was his only appearance for the Braves. Ennis pitched 16 innings in 12 appearances for the Detroit Tigers in 2004, posting an 8.44 ERA. He made his Philadelphia Phillies debut on August 26, 2007, pitching three innings and getting his first career save. Ennis was designated for assignment by the Phillies on February 26, 2008. On August 6, 2008, Ennis' contract was sold to the Samsung Lions of the Korea Baseball Organization where he pitched for the rest of the season.
On February 25, 2009, Ennis signed with the Lancaster Barnstormers of the independent Atlantic League, but on March 3, signed a minor league contract with the Philadelphia Phillies.
After pitching in the first game of the season, Ennis suffered an injury to his elbow and was told he needed Tommy John surgery which will end his season. The Phillies released him on November 10, 2009.