James Shapiro may refer to:

• Jim Shapiro (attorney), American attorney
• Jim Shapiro (drummer) (born 1965), American rock musician
• James Shapiro (physician), British-born Canadian doctor who developed the Edmonton protocol
• James A. Shapiro, American professor of biochemistry and molecular biology
• James S. Shapiro (born 1955), American professor of English and comparative literature, non-fiction author

[ Source: Wikipedia ]